NOX4

NADPH oxidaz 4, insanlarda NOX4 ile kodlanan ve NADPH oksidazların NOX ailesine üye enzim.^[1]

Oksijen algılama, tüm aerobik organizmalarda homeostaz için gereklidir. Nötrofil granülositlerdeki büyük miktarlarda reaktif oksijen türlerinin (ROS) üretiminden sorumlu olana benzer bir fagosit tipi oksidazın böbrekte, böbrek korteksindeki eritropoietin sentezini düzenleyen bir oksijen sensörü olarak işlev gördüğü ileri sürülmüştür.^[1]

Nox4, damar sistemini inflamatuvar strese karşı korur.^[2] Amino endoperoksitler tarafından Nox bağımlı reaktif oksijen türü modülasyonu, yüksek Nox4 eksprese eden kanser hücrelerinde apoptozu indükleyebilir.^[3]

• Lachgar A, Sojic N, Arbault S, ve diğerleri. (1999). "Amplification of the inflammatory cellular redox state by human immunodeficiency virus type 1-immunosuppressive tat and gp160 proteins". J. Virol. 73 (2): 1447-52. doi:10.1128/JVI.73.2.1447-1452.1999. PMC 103969 $2. PMID 9882350. 
• Geiszt M, Kopp JB, Várnai P, Leto TL (2000). "Identification of renox, an NAD(P)H oxidase in kidney". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 8010-4. doi:10.1073/pnas.130135897. PMC 16661 $2. PMID 10869423. 
• Shiose A, Kuroda J, Tsuruya K, ve diğerleri. (2001). "A novel superoxide-producing NAD(P)H oxidase in kidney". J. Biol. Chem. 276 (2): 1417-23. doi:10.1074/jbc.M007597200. PMID 11032835. 
• Cheng G, Cao Z, Xu X, ve diğerleri. (2001). "Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5". Gene. 269 (1–2): 131-40. doi:10.1016/S0378-1119(01)00449-8. PMID 11376945. 
• Brar SS, Kennedy TP, Sturrock AB, ve diğerleri. (2002). "An NAD(P)H oxidase regulates growth and transcription in melanoma cells". Am. J. Physiol., Cell Physiol. 282 (6): C1212-24. doi:10.1152/ajpcell.00496.2001. PMID 11997235. 
• Strausberg RL, Feingold EA, Grouse LH, ve diğerleri. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMC 139241 $2. PMID 12477932. 
• Kalinina N, Agrotis A, Tararak E, ve diğerleri. (2002). "Cytochrome b558-dependent NAD(P)H oxidase-phox units in smooth muscle and macrophages of atherosclerotic lesions". Arterioscler. Thromb. Vasc. Biol. 22 (12): 2037-43. doi:10.1161/01.ATV.0000040222.02255.0F . PMID 12482831. 
• Hilenski LL, Clempus RE, Quinn MT, ve diğerleri. (2004). "Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells". Arterioscler. Thromb. Vasc. Biol. 24 (4): 677-83. doi:10.1161/01.ATV.0000112024.13727.2c. PMID 14670934. 
• Ota T, Suzuki Y, Nishikawa T, ve diğerleri. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
• Mahadev K, Motoshima H, Wu X, ve diğerleri. (2004). "The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction". Mol. Cell. Biol. 24 (5): 1844-54. doi:10.1128/MCB.24.5.1844-1854.2004. PMC 350558 $2. PMID 14966267. 
• Chamulitrat W, Stremmel W, Kawahara T, ve diğerleri. (2004). "A constitutive NADPH oxidase-like system containing gp91phox homologs in human keratinocytes". J. Invest. Dermatol. 122 (4): 1000-9. doi:10.1111/j.0022-202X.2004.22410.x. PMID 15102091. 
• Vaquero EC, Edderkaoui M, Pandol SJ, ve diğerleri. (2004). "Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells". J. Biol. Chem. 279 (33): 34643-54. doi:10.1074/jbc.M400078200. PMID 15155719. 
• Schwarzer C, Machen TE, Illek B, Fischer H (2004). "NADPH oxidase-dependent acid production in airway epithelial cells". J. Biol. Chem. 279 (35): 36454-61. doi:10.1074/jbc.M404983200. PMID 15210697. 
• Guzik TJ, Sadowski J, Kapelak B, ve diğerleri. (2005). "Systemic regulation of vascular NAD(P)H oxidase activity and nox isoform expression in human arteries and veins". Arterioscler. Thromb. Vasc. Biol. 24 (9): 1614-20. doi:10.1161/01.ATV.0000139011.94634.9d. PMID 15256399. 
• Ambasta RK, Kumar P, Griendling KK, ve diğerleri. (2004). "Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase". J. Biol. Chem. 279 (44): 45935-41. doi:10.1074/jbc.M406486200. PMID 15322091. 
• Park HS, Jung HY, Park EY, ve diğerleri. (2004). "Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B". J. Immunol. 173 (6): 3589-93. doi:10.4049/jimmunol.173.6.3589 . PMID 15356101. 
• Gerhard DS, Wagner L, Feingold EA, ve diğerleri. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMC 528928 $2. PMID 15489334. 
• Jana A, Pahan K (2005). "Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase". J. Neurosci. 24 (43): 9531-40. doi:10.1523/JNEUROSCI.3085-04.2004. PMC 1955476 $2. PMID 15509740. 
• Pedruzzi E, Guichard C, Ollivier V, ve diğerleri. (2004). "NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells". Mol. Cell. Biol. 24 (24): 10703-17. doi:10.1128/MCB.24.24.10703-10717.2004. PMC 533993 $2. PMID 15572675. 
• Djordjevic T, BelAiba RS, Bonello S, ve diğerleri. (2005). "Human urotensin II is a novel activator of NADPH oxidase in human pulmonary artery smooth muscle cells". Arterioscler. Thromb. Vasc. Biol. 25 (3): 519-25. doi:10.1161/01.ATV.0000154279.98244.eb. PMID 15618545.