ARHGAP1

ARHGAP1
Uygun yapılar PDB Ortolog araması: PDBe RCSB PDB kimlik kodlarının listesi 1AM4, 1GRN, 1OW3, 1RGP, 1TX4, 2NGR
Tanımlayıcılar
Başka adlar	ARHGAP1
Dış kimlikler	OMIM: 602732 MGI: 2445003 HomoloGene: 20909 GeneCards: ARHGAP1
Gen yerleşimi (İnsan) Krom. 11. Kromozom (insan)[1] Bant 11p11.2 Başlangıç 46,677,080 bç[1] Bitiş 46,700,619 bç[1]
RNA ekspresyonu deseni Daha çok ekspresyon verisi başvurusu
Gen ontolojisi Moleküler işlevi • SH3 domain binding • GO:0001948, GO:0016582 protein bağlanması • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • cadherin binding Hücresel bileşeni • Sitozol • extracellular exosome • sitoplazma • endosome membrane • perinuclear region of cytoplasm • sorting endosome • membrane • integral component of membrane Biyolojik süreci • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • GO:0072468 Sinyal transdüksiyonu • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • small GTPase mediated signal transduction • positive regulation of signal transduction • transferrin transport • iron ion import across cell outer membrane • negative regulation of endocytic recycling • endosomal transport Kaynaklar:Amigo / QuickGO
Ortologlar
Türler	İnsan	Fare
Entrez	392	228359
Ensembl	ENSG00000175220	ENSMUSG00000027247
UniProt	Q07960	Q5FWK3
RefSeq (mRNA)	NM_004308	NM_001145902 NM_146124 NM_001359970
RefSeq (protein)	NP_004299	NP_001139374 NP_666236 NP_001346899
Yerleşim (UCSC)	Krom. 11: 46.68 – 46.7 Mb	n/a
PubMed araması	[2]	[3]
Vikiveri
İnsan'ı Gör/Düzenle Fare'yi Gör/Düzenle

Rho GTPaz etkinleştirici protein 1, insanlarda ARHGAP1 geni tarafından kodlanan bir enzimdir.^[4][5]

Aşağıdakilerin ARHGAP1 ile etkileşime girdiği gösterilmiştir:

• BNIP2,^[6]
• CDC42^{[7][8][9][10]} ve
• RHOA.^[11][12]

• Diekmann D, Brill S, Garrett MD, Totty N, Hsuan J, Monfries C, Hall C, Lim L, Hall A (1991). "Bcr encodes a GTPase-activating protein for p21rac". Nature. 351 (6325). ss. 400-2. doi:10.1038/351400a0. PMID 1903516. 
• Garrett MD, Major GN, Totty N, Hall A (1991). "Purification and N-terminal sequence of the p21rho GTPase-activating protein, rho GAP". Biochem. J. 276 (Pt 3) (3). ss. 833-6. PMC 1151079 $2. PMID 1905930. 
• Barfod ET, Zheng Y, Kuang WJ, Hart MJ, Evans T, Cerione RA, Ashkenazi A (1993). "Cloning and expression of a human CDC42 GTPase-activating protein reveals a functional SH3-binding domain". J. Biol. Chem. 268 (35). ss. 26059-62. PMID 8253717. 
• Aspenström P, Lindberg U, Hall A (1996). "Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome". Curr. Biol. 6 (1). ss. 70-5. doi:10.1016/S0960-9822(02)00423-2. PMID 8805223. 
• Barrett T, Xiao B, Dodson EJ, Dodson G, Ludbrook SB, Nurmahomed K, Gamblin SJ, Musacchio A, Smerdon SJ, Eccleston JF (1997). "The structure of the GTPase-activating domain from p50rhoGAP". Nature. 385 (6615). ss. 458-61. doi:10.1038/385458a0. PMID 9009196. 
• Hu KQ, Settleman J (1997). "Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation". EMBO J. 16 (3). ss. 473-83. doi:10.1093/emboj/16.3.473. PMC 1169651 $2. PMID 9034330. 
• Rittinger K, Walker PA, Eccleston JF, Nurmahomed K, Owen D, Laue E, Gamblin SJ, Smerdon SJ (1997). "Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP". Nature. 388 (6643). ss. 693-7. doi:10.1038/41805. PMID 9262406. 
• Zhang B, Wang ZX, Zheng Y (1997). "Characterization of the interactions between the small GTPase Cdc42 and its GTPase-activating proteins and putative effectors. Comparison of kinetic properties of Cdc42 binding to the Cdc42-interactive domains". J. Biol. Chem. 272 (35). ss. 21999-2007. doi:10.1074/jbc.272.35.21999. PMID 9268338. 
• Li R, Zhang B, Zheng Y (1997). "Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain of p190". J. Biol. Chem. 272 (52). ss. 32830-5. doi:10.1074/jbc.272.52.32830. PMID 9407060. 
• Zhang B, Zheng Y (1998). "Regulation of RhoA GTP hydrolysis by the GTPase-activating proteins p190, p50RhoGAP, Bcr, and 3BP-1". Biochemistry. 37 (15). ss. 5249-57. doi:10.1021/bi9718447. PMID 9548756. 
• Low BC, Lim YP, Lim J, Wong ES, Guy GR (1999). "Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42". J. Biol. Chem. 274 (46). ss. 33123-30. doi:10.1074/jbc.274.46.33123. PMID 10551883. 
• Graham DL, Eccleston JF, Chung CW, Lowe PN (1999). "Magnesium fluoride-dependent binding of small G proteins to their GTPase-activating proteins". Biochemistry. 38 (45). ss. 14981-7. doi:10.1021/bi991358e. PMID 10555980. 
• Low BC, Seow KT, Guy GR (2000). "Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2". J. Biol. Chem. 275 (19). ss. 14415-22. doi:10.1074/jbc.275.19.14415. PMID 10799524. 
• Low BC, Seow KT, Guy GR (2000). "The BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAP". J. Biol. Chem. 275 (48). ss. 37742-51. doi:10.1074/jbc.M004897200. PMID 10954711. 
• Zhou YT, Soh UJ, Shang X, Guy GR, Low BC (2002). "The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence". J. Biol. Chem. 277 (9). ss. 7483-92. doi:10.1074/jbc.M109459200. PMID 11741952. 
• Fidyk NJ, Cerione RA (2002). "Understanding the catalytic mechanism of GTPase-activating proteins: demonstration of the importance of switch domain stabilization in the stimulation of GTP hydrolysis". Biochemistry. 41 (52). ss. 15644-53. doi:10.1021/bi026413p. PMID 12501193. 
• Qin W, Hu J, Guo M, Xu J, Li J, Yao G, Zhou X, Jiang H, Zhang P, Shen L, Wan D, Gu J (2003). "BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis". Biochem. Biophys. Res. Commun. 308 (2). ss. 379-85. doi:10.1016/S0006-291X(03)01387-1. PMID 12901880. 
• Shang X, Zhou YT, Low BC (2003). "Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1". J. Biol. Chem. 278 (46). ss. 45903-14. doi:10.1074/jbc.M304514200. PMID 12944407. 

• Human ARHGAP1 30 Aralık 2019 tarihinde Wayback Machine sitesinde arşivlendi. genome location and ARHGAP1^[] gene details page in the UCSC Genome Browser.