ACER3

ACER3
Tanımlayıcılar
Başka adlar	ACER3
Dış kimlikler	OMIM: 617036 MGI: 1913440 HomoloGene: 5410 GeneCards: ACER3
Gen yerleşimi (İnsan)
Krom.	11. Kromozom (insan)
Bitiş	77,026,797 bç
Gen ontolojisi
Moleküler işlevi	• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; • hydrolase activity; • phytoceramidase activity; • N-acylsphingosine amidohydrolase activity; • dihydroceramidase activity; • ceramidase activity; • calcium ion binding; • zinc ion binding; • metal ion binding;
Hücresel bileşeni	• integral component of membrane; • integral component of Golgi membrane; • integral component of endoplasmic reticulum membrane; • Golgi membrane; • Golgi aygıtı; • endoplasmic reticulum membrane; • Endoplazmik retikulum; • membrane;
Biyolojik süreci	• sphingosine biosynthetic process; • sphingolipid biosynthetic process; • phytosphingosine biosynthetic process; • ceramide metabolic process; • positive regulation of cell population proliferation; • inflammatory response; • myelination; • regulation of programmed cell death; • ceramide catabolic process; • lipid metabolism; • sphingolipid metabolic process;
	Kaynaklar:Amigo / QuickGO
Ortologlar
	55331
	66190
	ENSG00000078124
	ENSMUSG00000030760
	Q9NUN7
	Q9D099
	NM_001300953; NM_001300954; NM_001300955; NM_018367
	NM_025408
	NP_001287882; NP_001287883; NP_001287884; NP_060837
	NP_079684; NP_001347544; NP_001347545; NP_001347546
	Vikiveri
İnsan'ı Gör/Düzenle	Fare'yi Gör/Düzenle

Alkalin seramidaz 3, insanların 11. kromozomunda yer alan ACER3 geni tarafından kodlanan bir seramidaz enzimidir.^[4]^[5]

Kaynakça

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000078124 - Ensembl, May 2017
^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mao C, Xu R, Szulc ZM, Bielawska A, Galadari SH, Obeid LM (July 2001). "Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide". J. Biol. Chem. 276 (28). ss. 26577-88. doi:10.1074/jbc.M102818200. PMID 11356846.
^ Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys. Acta. 1781 (9). ss. 424-34. doi:10.1016/j.bbalip.2008.06.002. PMC 2614331 $2. PMID 18619555.

Ek okuma

Strausberg RL, Feingold EA, Grouse LH, ve diğerleri. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26). ss. 16899-903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241 $2. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, ve diğerleri. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B). ss. 2121-7. doi:10.1101/gr.2596504. PMC 528928 $2. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, ve diğerleri. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1). ss. 40-5. doi:10.1038/ng1285. PMID 14702039.
Wheeler HE, Metter EJ, Tanaka T, ve diğerleri. (2009). Gibson G (Ed.). "Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging". PLOS Genet. 5 (10). ss. e1000685. doi:10.1371/journal.pgen.1000685. PMC 2752811 $2. PMID 19834535.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000078124 - Ensembl, May 2017

[2] "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11356846-4] Mao C, Xu R, Szulc ZM, Bielawska A, Galadari SH, Obeid LM (July 2001). "Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide". J. Biol. Chem. 276 (28). ss. 26577-88. doi:10.1074/jbc.M102818200. PMID 11356846.

[pmid18619555-5] Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys. Acta. 1781 (9). ss. 424-34. doi:10.1016/j.bbalip.2008.06.002. PMC 2614331 $2. PMID 18619555.

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Kaynakça

Ek okuma

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